Specificity: CDX-2 expression is restricted to nuclear staining in positive cells while CEA expression is restricted mostly to the lumen of colorectal crypts. The CEA antibody (COL-1) shows no reaction with a variety of normal tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, gallbladder, urachus, salivary gland, ovary, and endocervix.
Immunogen: Rabbits were injected with a synthetic peptide corresponding to residues near the C-terminus of human CDX-2. BALB/C mice were injected with Human colon carcinoma cell extracts (CEA).
Information: CEA: Adenocarcinoma of colon, intestine, ovary, lung, cervix, gallbladder, stomach.