Specificity: CDX-2 expression is restricted to nuclear staining in positive cells while CK7 expression is restricted to most glandular and transitional epithelia including lung, breast, bladder, and the female genital tract and their adenocarcinomas, but not in most gastrointestinal epithelium, prostate, hepatocyte, and squamous epithelium.
Immunogen: Rabbits were injected with a synthetic peptide corresponding to residues near the C-terminus of human CDX-2. BALB/C mice were injected with OTN11-ovarian cell carcinoma cell line.
Information: CK7: Carcinoma of ovary, lung, cervix, or breast.