Chk1 (phospho Ser345) antibody (HL122)

Clone Name: HL122

Light Chain: Kappa

Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 54

Form: Liquid

Buffer (with preservative): PBS, no preservative.

Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)

Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot ID: O14757

Antigen Species: Human

Immunogen: Carrier-protein conjugated synthetic peptide surrounding phospho Ser345 of human Chk1. The exact sequence is proprietary.

Purification: Affinity purified by Protein A.

Conjugation: Unconjugated

Full Name: checkpoint kinase 1

• Artikelnummer: GTX635572-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX635572-100
• Green Labware: Nein
• Verpackungseinheit: 100 μl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunocytochemistry
• Isotyp: IgG
• Human Gene ID: 1111
• Wirt: Rabbit