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Encompassing Amino Acids: 1-220(end)
Application: Useful for for SPR analysis, animal immunization, ELISA and PK assay.
Assay Conditions: Immobilized Human Claudin 6 VLP at 5 µg/mL(100 µl/Well).
Background: Claudins are integral membrane proteins and major components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-6 is one of the 27 members of the claudin family. Claudin-6 is widely expressed in various tumors but rarely expressed in healthy adult tissues. This cancer specific expression of claudin-6 makes it a promising target as an antigen for cancer immunotherapy. Several therapeutics that target claudin-6 are currently in development or in clinical trials including bispecific antibodies, monoclonal antibodies, and CAR-T cell therapy products.
Biological Activity: Dose response curve for Anti-Claudin 6 Antibody, mFc Tag with the EC50 of ‰¤5.5 ng/mL determined by ELISA.
Description: Human Claudin-6 (CLDN6) protein (VLP), full length encompassing amino acids 1-220(end). This construct is tag-free and was produced using VLP (virus-like particle) technology.
Endotoxin Level: <1 EU/µg (determined by LAL method)
Format: Aqueous buffer solution
Formulation: Supplied as a 0.2 µm filtered solution of PBS, pH 7.4. Notice: If you need it for immunization, Do Not use any adjuvant.
Purity: ≥95% (determined by HPLC)
Storage Stability: Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Uniprot: P56747
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
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