ClCN3 Antibody, Clone N258/5: APC

Mouse Anti-Rat Clcn3 Monoclonal IgG1

Target: ClCN3

Conjugate: APC

Product Type: Monoclonal

Clone Number: N258/5 (Formerly sold as S258-5)

Immunogen: Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3

Swiss-Prot: P51792

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~90kDa. Does not cross-react with Clcn4 or Clcn5 (based on KO validation results).

Cellular Localization: Membrane,Endosome,Endosome membrane,Cytoplasmic Vesicle,Secretory Vesicle Membrane

Scientific Background: Clcn3 mediates the exchange of chloride ions against protons, and functions as an antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could also help neuronal cells to establish short-term memory.

References: 1.  www.phosphosite.org/proteinAction.do?id=5088&showAllSites=true

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-408D-APC
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-408D-APC
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 84360
• Wirt: Mouse