Cleaved Caspase-1 p20 Polyclonal Antibody, Rabbit

Cleaved Caspase-1 p20 Polyclonal Antibody, Rabbit
Artikelnummer
ELSE-AB-93278-120
Verpackungseinheit
120 µl
Hersteller
Elabscience Biotechnology

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Abbreviation: Cleaved Caspase-1 p20

Target Synonym: CASP1;ICE;IL1BC;P45;caspase-1;Caspase 1

Conjugation: Unconjugated

UNIProt ID: P29466

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Concentration: 1mg/mL

Immunogen: A synthetic peptide of human Cleaved Caspase-1 p20

Dilution: IHC 1:50-1:100,IF 1:50-1:200
Mehr Informationen
Artikelnummer ELSE-AB-93278-120
Hersteller Elabscience Biotechnology
Hersteller Artikelnummer ELA-E-AB-93278-120
Green Labware Nein
Verpackungseinheit 120 µl
Mengeneinheit STK
Reaktivität Human, Mouse (Murine)
Klonalität Polyclonal
Methode Immunofluorescence, Immunohistochemistry
Isotyp IgG
Wirt Rabbit
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