Collagen Type I, porcine

Collagen Type I, porcine, Host: Rabbit, Polyclonal

Background: Type I Collagen usually exists as a heterotrimer formed by alpha 1(I) and alpha 2(I) chains and is found in bone, cornea, skin and tendon. In foetal tissues also homotrimers of alpha-1(I) are found, but they are not constituents of normal adult tissues. Collagens consist of a family of highly specialized glycoproteins of which at least 16 genetically distinct types are known to date. The basal unit of a collagen molecule consists of a triple-helical structure formed by 3 alpha-chains. Predominant amino acids are glycine, proline and hydroxproline. Regularly also lysines and hydroxylysines occur, which are responsible for cross-linkage and glycosylation of the protein chains. Different composition of alpha-chains and different glycosylation contribute to the high variability of collagens in different tissues and organs. Porcine Collagen Type I, cross-reactivity with collagen type III <1%, Collagen type II, IV, V Elastin and Fibronectin <0.1%.

Positive Control: Porcine skin or tendon.

Immunogen: Purified collagen type I from porcine tendon.

Purification Method: affinity purified antibody lyophilized from phosphate buffered solution; no BSA and preservative added!.

Concentration: app. 1 mg/ml.

References: 1. Rousseau C.F, Gagnieu C.H. (2002) In vitro cytocompatibility of porcine type I atelocollagen crosslinked by oxidized glycogen. Biomaterials 23, 1503-1510. 2. Beard HK, Ryvar R, Brown R, Muir H. (1980) Immunochemical localization of collagen types and proteoglycan in pig intervertebral discs. Immunology. Oct;41(2):491-501.

Caution: *These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

• Artikelnummer: BILCO20191-0.1
• Hersteller: BioLogo
• Hersteller Artikelnummer: CO20191-0.1
• Green Labware: Nein
• Verpackungseinheit: 0,1 ml
• Mengeneinheit: STK
• Reaktivität: Pig (Porcine)
• Klonalität: Polyclonal
• Methode: Immunofluorescence, Immunohistochemistry (paraffin), Western Blotting, ELISA, Radioimmunoassay (RIA)
• Wirt: Rabbit