Copper Transporting ATPase 2 Antibody, Clone L62/29: APC

Mouse Anti-Human Copper Transporting ATPase 2 Monoclonal IgG1

Target: ATP7B

Conjugate: APC

Product Type: Monoclonal

Clone Number: L62/29 (Formerly sold as S62-29)

Immunogen: Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATPase2

Swiss-Prot: B7ZLR4

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~160kDa in rat brain membrane preparations.

Cellular Localization: Cytoplasm,Mitochondrion,Golgi Apparatus,Trans-Golgi Network Membrane

Scientific Background: The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver, characterized by neurological symptoms and hepatic damage.

References: 1. Tanzi R.E., et al. (1993) Nature Genetics. 5: 344-350.2. Ghr/nlm.gov/gene/ATP7B

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-399D-APC
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-399D-APC
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunoprecipitation, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 540
• Wirt: Mouse