CRE/CREB Reporter (Luc) - Jurkat Cell Line (cAMP/PKA Signaling Pathway)

CRE/CREB Reporter (Luc) - Jurkat Cell Line (cAMP/PKA Signaling Pathway)
Artikelnummer
BPS79636
Verpackungseinheit
2 vials
Hersteller
BPS Bioscience

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Applications: Monitor cAMP/PKA signaling pathway activity and screen for activators or inhibitors of cAMP/PKA signaling pathway.

Description: The CRE/CREB Reporter (Luc) - Jurkat Cell Line contains a firefly luciferase gene under the control of multimerized cAMP response element (CRE) stably integrated into Jurkat cells. Elevation of the intracellular cAMP level activates cAMP response element binding protein (CREB) to bind CRE and induces the expression of luciferase. This cell line is validated for response to stimulation by Forskolin.

Host Cell Line: Jurkat

Mycoplasma Testing: The cell line has been screened using the PCR-based Venor™GeM Mycoplasma Detection kit (Sigma-Aldrich, #MP0025) to confirm the absence of Mycoplasma species.

Storage Stability: Immediately upon receipt, store in liquid nitrogen.

Supplied As: Each vial contains ~2 X 10^6 cells in 1 ml of 10% DMSO

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: BSL-1

References: 1. Montminy, M.R. et al. (1987) Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature 328(6126): 175-178. 2. Fan Chung, K. (2006) Phosphodiesterase inhibitors in airways disease. Eur. J. Pharmacol. 533(1-3): 110-117.
Mehr Informationen
Artikelnummer BPS79636
Hersteller BPS Bioscience
Hersteller Artikelnummer 79636
Verpackungseinheit 2 vials
Mengeneinheit PAK
Wirt Human
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