Cyclosporine, CAS 59865-13-3

Immunosuppressant

Product Type: Inhibitor

CAS No.: 59865-13-3

MolecularFormula: C62H111N11O12

Molecular Weight: 1202,63

Source: Synthetic

Purity: >99%

Solubility: Soluble to 100 mM in DMSO, 50 mM in ethanol

Appearance: White Solid

PubChem CID: 5284373

Scientific Background: Cyclosporin A is a hydrophobic cyclic peptide, and is a potent immune-suppressant and antifungal. It acts via its ability to bind to a family of intracellular proteins (1). The immunosuppressant action is mediated by the complex Cyclosporin-A-cyclophilin that specifically inhibits the Ca2+/calmodulin-dependent serine-threonine-protein phosphatase-2B. This is turn inhibits calcineurin and promotes dephosphorylation of transcription factor NF-AT and T-cell activation (2).

References: 1. Heitman J., et al. (1992) New Biol. 4:448.2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-201-100MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-201-100MG
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK