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Encompassing Amino Acids: 30-300e
Application: Useful for TL1A binding studies and for screening binding inhibitors.
Assay Conditions: Assay was done according to DcR3:TL1A Inhibitor Screening Assay Kit (#82160). Increasing amounts of DcR3 were coated on a plate and TL1A, His-Tag, Avi-Tag, Biotin-Labeled Recombinant (#101882) was used as binding partner.
Background: Decoy receptor 3 (DcR3) is a soluble receptor of the tumor necrosis factor receptor superfamily of proteins (TNFRSF), which associates with its respective ligands, such as TL1A, FasL and LIGHT. DcR3 has been recognized as a significant anti-apoptotic factor with prominent involvement in various inflammatory and neoplastic conditions. Increased intratumor expression of DcR3 and elevated soluble DcR3 protein content in the sera of patients has been reported for various malignancies. TL1A, also called TNFSF15, is a member of the tumor necrosis factor family. It is expressed in different immune cells, such as monocyte, macrophage, dendritic cell, T cell and non-immune cells. TL1A competitively binds to DcR3, providing stimulatory signal for downstream signaling pathways, and then regulates proliferation, activation, apoptosis, and chemokine production in effector cells. Inhibition of DcR3-TL1A interaction has substantial therapeutic potential.
Description: Recombinant human DcR3 (Decoy receptor 3), encompassing amino acids 30-300(end). This construct contains a C-terminal His-tag (10xHis). This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_003823.4
Purity: ≥90%
Supplied As: At least 6 months at -80°C.
Tags: Tumor necrosis factor receptor superfamily member 6B, TNFRSF6B, Decoy receptor 3 (DcR3), Decoy receptor for Fas ligand, M68, TR6
Target: C-terminal His-Tag
Uniprot: O95407
Warnings: Avoid multiple freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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