Desmoglein-3 (Squamous Cell Marker) (5H10), 1mg/mL

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Description: This antibody recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (>80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Product Origin: Animal - Mus musculus (mouse)

Clone: 5H10

Entrez Gene ID: 1830

Immunogen: Recombinant human DSG3 extracellular protein fragment (exact sequence is proprietary)

Expected AB Applications: Immuofluorescence (published for clone)/Flow, surface (published for clone)/IP (published for clone)/WB (published for clone)

Z-Antibody Applications: Flow, surface (published)/IF (published)/IP (published)/WB (published)

• Artikelnummer: BTMBNUM1440-50
• Hersteller: Biotium
• Hersteller Artikelnummer: BNUM1440-50
• Verpackungseinheit: 50 uL
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunoprecipitation, Western Blotting, Flow Cytometry
• Isotyp: IgG1 kappa
• Wirt: Mouse
• Konjugat: Unconjugated