DHCR7 antibody

Application Note: WB: 1:2000. ICC/IF: 1:10-1:50. IHC-P: 1:50-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 54

Form: Liquid

Buffer (with preservative): PBS, 0.09% (W/V) sodium azide.

Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)

Background: This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by cognitive disability, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Aug 2009]

Uniprot ID: Q9UBM7

Antigen Species: Human

Immunogen: KLH conjugated synthetic peptide between 437-463 amino acids from the C-terminal region of human DHCR7.

Purification: Protein A purified followed by peptide affinity purification

Conjugation: Unconjugated

Full Name: 7-dehydrocholesterol reductase

• Artikelnummer: GTX04343-400
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX04343-400
• Green Labware: Nein
• Verpackungseinheit: 400 μl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Polyclonal
• Methode: Immunofluorescence, Immunohistochemistry (paraffin), Western Blotting, Immunocytochemistry
• Isotyp: IgG
• Human Gene ID: 1717
• Wirt: Rabbit