Dicer Antibody, Clone N167/7: HRP

Mouse Anti-Mouse Dicer Monoclonal IgG1

Target: Dicer

Conjugate: HRP

Product Type: Monoclonal

Clone Number: N167/7 (Formerly sold as S167-7)

Immunogen: Fusion protein amino acids 1638-1899 of mouse Endoribonuclease Dicer

Swiss-Prot: Q8R418

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~215kDa.

Cellular Localization: Cytoplasm

Scientific Background: Dicer is a member of the RNase III family that specifically cleaves double-stranded RNAs to generate microRNAs (miRNAs) (1). After long primary transcript pri-miRNAs are processed to stem-looped pre-miRNAs by Drosha (2), pre-miRNAs are transported to the cytoplasm and further processed by Dicer to produce 22-nucleotide mature miRNAs (3). The mature miRNA then becomes a part of the RNA-Induced Silencing Complex (RISC) and can bind to the 3' UTR of the target mRNA (3)

References: 1. Hutvágner G. and Zamore P.D. (2002) Science 297: 2056-60.2. Lee Y., et al. (2003) Nature 425: 415-9.3. Diederichs S. and Haber, D.A. (2007) Cell 131: 1097-108.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-416D-HRP
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-416D-HRP
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 192119
• Wirt: Mouse