Dimethyloxaloylglycine (DMOG), CAS 89464-63-1

Prolyl-4-hydroxylase inhibitor

Product Type: Inhibitor

CAS No.: 89464-63-1

MolecularFormula: C6H9NO5

Molecular Weight: 175,1

Source: Synthetic

Purity: >99%

Solubility: Soluble in DMSO (>25 mg/ml), 100% ethanol (>25 mg/ml) or dimethyl formamide, or PBS pH7.2 (10 mg/ml)

Appearance: Off-white solid

PubChem CID: 560326

Scientific Background: DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.

References: 1. Grozinger C.M., et al. (2001) J. Biol. Chem. 276(42): 38837-43. 2. Mai A., et al. (2005) J. Med. Chem. 48(24): 7789-95. 3. Kahyo T., et al. (2008) J. Pharmacol. Sci. 108(3): 364-71.4. Jung-Hynes B., et al. (2009) J. Biol. Chem. 284(6): 3823-32.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-382-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-382-50MG
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK