Dityrosine Antibody, Clone 10A6: HRP

Mouse Anti-Dityrosine (DT) Monoclonal IgG1

Target: Dityrosine

Conjugate: HRP

Product Type: Monoclonal

Clone Number: 10A6

Immunogen: Synthetic Dityrosine conjugated to Keyhole Limpet Hemocyanin (KLH).

Purification: Protein G Purified

Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Specific for dityrosine modified proteins. Does not cross-react with 3,5-dibromotyrosine or bromotyrosine modified proteins.

Scientific Background: ROS such as hydrogen peroxide (H2O2), superoxide, and hydroxyl radicals can react with both the backbone and the side chains of proteins, leading to backbone cleavage and side-chain modifications, respectively. Peroxidases, UV radiation, and hydroxyl radicals catalyze the formation of tyrosyl radicals which then react to form cross-links between proteins (1). This produces dityrosine, a metabolically stable biomarker of protein oxidation (2).

References: 1. Malencik, D. A., Anderson, S. R. (2003) Amino Acids. 25(3-4):233-247.2. Giulivi, C., Davies, K. J. A. (2001) J Biol Chem. 276, 24129-24136.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-521D-HRP
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-521D-HRP
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Various species
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, ELISA, Flow Cytometry, Immunocytochemistry, Fluorescence-Activated Cell Sorting (FACS)
• Isotyp: IgG1
• Wirt: Mouse