Formulation: A solid
Formal Name: 2,6-anhydro-5-[[[(3′R,4′S,5′R)-6′′-chloro-4′-(2-chloro-3-fluoro-4-pyridinyl)-1′′,2′′-dihydro-4,4-dimethyl-2′′-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3′′-[3H]indol]-5′-yl]carbonyl]amino]-3,4,5-trideoxy-L-erythro-hexonamide
Purity: ≥98%
Formula Markup: C30H34Cl2FN5O4
Formula Weight: 618,5
Shelf life (days): 1460
CAS Number: 1398568-47-2
Notes: DS-3032 is an inhibitor of the protein-protein interaction between murine double minute 2 (MDM2) and p53.{68913} It induces apoptosis in WaGa and PeTa Merkel cell carcinoma cells when used at a concentration of 100 nM. DS-3032 (1 µM) decreases the viability of p53 wild-type MKL-1 cells but not p53 knockout MLK-1 cells. In vivo, DS-3032 (100 mg/kg per day) reduces tumor volume and increases survival in a patient-derived xenograft (PDX) mouse model of Merkel cell carcinoma.
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