Formulation: A solid
Formal Name: 9-[(phenylmethoxy) imino]-9H-indeno[1,2-b] pyrazine-2,3-dicarbonitrile
Purity: ≥95%
Formula Markup: C20H11N5O
Formula Weight: 337,3
Shelf life (days): 1460
CAS Number: 924296-18-4
Notes: DUB-IN-1 is an inhibitor of ubiquitin-specific protease 8 (USP8; IC50 = 0.85 µM).{62998} It is selective for USP8 over USP7 (IC50 = >100 µM). It inhibits the proliferation of LN-229, U87MG, and T98G glioblastoma cells when used at concentrations ranging from 200 to 800 nM.{67920} DUB-IN-1 (500 and 800 nM) reduces the migration and stemness of LN-229 and T98G cells and sensitizes both to ionizing radiation. It also reduces the viability of a variety of esophageal squamous cell carcinoma (ESCC) cells (IC50s = 1.58-2.14 µM) and induces apoptosis, autophagy, and cell cycle arrest at the G2/M phase in KYSE-450 and KYSE-30 ESCC cells.{67921}
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