English
DUSP6 Polyclonal Antibody, Rabbit
DUSP6 Polyclonal Antibody, Rabbit
Artikelnummer
ELSE-AB-92518-60
Verpackungseinheit
60 µl
Hersteller
Elabscience Biotechnology
Verfügbarkeit:
wird geladen...
Preis wird geladen...
Abbreviation: DUSP6
Target Synonym: DUSP6;HH19;MKP3;PYST1
Conjugation: Unconjugated
UNIProt ID: Q16828
Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human DUSP6
Dilution: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:50-1:200
Target Synonym: DUSP6;HH19;MKP3;PYST1
Conjugation: Unconjugated
UNIProt ID: Q16828
Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human DUSP6
Dilution: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:50-1:200
| Artikelnummer | ELSE-AB-92518-60 |
|---|---|
| Hersteller | Elabscience Biotechnology |
| Hersteller Artikelnummer | ELA-E-AB-92518-60 |
| Green Labware | Nein |
| Verpackungseinheit | 60 µl |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine), Rat (Rattus) |
| Klonalität | Polyclonal |
| Methode | Immunofluorescence, Western Blotting, Immunohistochemistry |
| Isotyp | IgG |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
Verwandte Artikel
Markieren Sie die Artikel, um Sie dem Warenkorb hinzuzufügen oder
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
