DUX4 Antibody, Clone P2B1: HRP

Mouse Anti-Human DUX4 Monoclonal IgG1

Target: DUX4

Conjugate: HRP

Product Type: Monoclonal

Clone Number: P2B1

Immunogen: C-terminal 76 amino acids of Human DUX4 with glutathione-s-transferase (gst) tag

Swiss-Prot: F5GZ66

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~45kDa. No cross-reactivity with DUX4c.

Cellular Localization: Nucleus

Scientific Background: DUX4, or double homeobox4, is a human protein that is a transcriptional activator of paired-like homeodomain transcription factor 1 (1). Clinically it is a facioscapulohumeral muscular dystrophy candidate gene that appears to have a toxic gain of function (2-4). In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues (5).

References: 1. Entrez Gene: “Dux4 Double Homeobox, 4”2. Dixit M., et al., (2007) Proc. Natl Acad Sci. USA. 104(46): 18157-18162.3. Kowaljow V., et al. (2007) Neuromuscl Disord. 17(8): 611-623.4. Lemmers R., et al. (2010) Science Express. 329(5999): 1650-1653.5. Snider L., et al. (2010) PLoS Genetics. 6:1-14.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-192D-HRP
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-192D-HRP
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 22947
• Wirt: Mouse