Eicosanoyl-5-hydroxytyptamide, CAS N/A

A neuroprotective natural product found in coffee

Product Type: Inhibitor

CAS No.: N/A

MolecularFormula: C30H50N2O2

Molecular Weight: 470,7

Source: Synthetic

Purity: >98% (TLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (30 mg/ml); or ethanol (20 mg/ml, warm)

Appearance: Beige powder

Scientific Background: A natural product found in coffee which synergizes with caffeine in protecting the brain in models of alpha-synucleinopathy (1). It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated alpha-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. It prevents ABeta-induced impairments in mouse models of Alzheimer’s disease (2,3).

References: 1. Yan R., et al. (2018) Proc. Natl. Acad. Sci. USA . 115:E120532. Asam K., et al. (2017) PLoS One. 12:e01894133. Basurto-Islas G., et al. (2014) Neurobiol. Aging. 35:2701

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-615-10MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-615-10MG
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK