Product Type: Inhibitor
CAS No.: 49843-98-3
MolecularFormula: C13H13ClN2O
Molecular Weight: 248,7
Source: Synthetic
Purity: >98% (TLC), NMR conforms
Solubility: Soluble in 18 mg/ml DMSO or 10 mg/ml Ethanol
Appearance: Light Yellow Solid
PubChem CID: 5113032
Scientific Background: Selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable.
References: 1. Solomon J.M., et al., (2006) Mol. Cell. Biol. 26: 28.2. Anderson J.L., et al., (2011) Mol.Cell 43: 834.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.