Fasudil, CAS 103745-39-7

ROCK inhibitor

Product Type: Inhibitor

CAS No.: 103745-39-7

MolecularFormula: C14H17N3O2S•HCl

Molecular Weight: 327,83

Source: Synthetic

Purity: ≥98% (TLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (75 mg/ml) or water (100 mg/ml)

Appearance: Powder

PubChem CID: 3547

Scientific Background: Fasudil is a ROCK2 inhibitor with some action on PRK2 and MSK1 (IC50 values are 1.9 µM, 4 µM and 5 µM respectively). It is also shown to inhibit RSK1, RSK2, PKA, AMPK and PKd1. It is also a calcium channel antagonist and vasodilator.

References: 1. Shirotani M., et al. (1991) J. Pharmacol. Exp. Ther. 259(2): 738-744.2. Arai M., Nozawa R., et al. (1993) Biochem. Pharmacol. 46(8): 1487-1490.3. Satoh S., et al. (1996) Br. J. Pharmacol. 118(7): 1592-1606.4. Sward K., et al. (2000) J. Physiol. 522: 33-49.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-371-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-371-50MG
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK