Felodipine, CAS 72509-76-3

L-type Ca channel blocker

Product Type: Inhibitor

CAS No.: 72509-76-3

MolecularFormula: C18H19Cl2NO4

Molecular Weight: 384,25

Source: Synthetic

Purity: >98% (TLC); NMR (Conforms)

Solubility: Soluble to 100 mM in ethanol and to 100 mM in DMSO

Appearance: Light Yellow Solid

PubChem CID: 3333

Scientific Background: Felodipine is an L-type Ca2+ channel blocker (1). In isolated rat ventricular myocytes, using a whole-cell patch-clamp technique, it displays a Ki of 11 nM (2). It is a clinically useful antihypertensive agent (3) which attenuates the hypertrophic effect of cyclosporine on transplanted hearts (4).

References: 1. Furakawa T., et al. (2005) J Cardiovasc. Pharmacol. 45(3): 241-246.2. Zahradnikova Z., Minarovic I., Zahradnik I. (2007) J Pharmacol Exp. Ther. 322(2): 638-645.3. Manzo B.A., Matalka M.S., Ravnan S.L. (2003) Pharmacotherapy. 23(11): 1508-1512.4. Schwitter J., et al. (1999) J Heart Lung Transplant. 18(10): 1003-1013.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-323-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-323-50MG
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK