Ferrostatin-1, CAS 347174-05-4

Ferroptosis Inhibitor

Product Type: Inhibitor

CAS No.: 347174-05-4

MolecularFormula: C15H22N2O2

Molecular Weight: 262,4

Source: Synthetic

Purity: >98% (TLC); NMR (Conforms)

Solubility: Soluble in DMSO (100 mg/ml) or ethanol (100 mg/ml)

Appearance: Tan powder

Scientific Background: Ferrostatin-1 inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death. It is especially potent of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices (1). It also blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells (2), and inhibits oxidative lipid damage and cell death in diverse disease models (3).

References: 1. Dixon S.J., et al. (2012) Cell. 149: 1060.2. Louandre C., et al. (2013) Int. J. Cancer. 133: 1732.3. Skouta R., et al. (2014) J. Am. Chem. Soc. 136: 4551.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-525-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-525-25MG
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: PAK