FK506, CAS 104987-11-3

FKBP inhibitor

Product Type: Inhibitor

CAS No.: 104987-11-3

MolecularFormula: C44H69HO12

Molecular Weight: 804

Source: Synthetic

Purity: >98%

Solubility: May be dissolved in DMSO (50 mg/mL) or ethanol (50mg/mL)

Appearance: White powder

PubChem CID: 445643 

Scientific Background: FK506 or Fujimycin or Tacrolimus, is an immunosuppressant. It is mainly used after allogeneic organ transplants, but can also be used topically in the treatment of eczema, uveitis and vitiligo (1). It is a macrolide that prevents the dephosphorylation of NF-AT. It reduces peptidyl-prolyl isomerase activity by binding to FKBP12 creating a new complex that interacts with and inhibits calcineurin (2, 3).

References: 1. Nanette B., et al. (2004) J Am Acad Derm. 51(5): 760-766.2. Ganong W.F., Review of Medical Physiology (22nd ed.) Lange Medical Books. P.5303. Liu J. Lane W., Friedman J, Weissman I and Schreiber S. (1991) Cell. 66(4): 807-815

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-214-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-214-50MG
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK