Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: FKBP3 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FKBP3
Key Reference: Meng,X., Biochem. Genet. 40 (9-10), 303-310 (2002)
Molecular Weight: 25kDa
Peptide Sequence: Synthetic peptide located within the following region:
EALLTMSKGEKARLEIEPEWAYGKKGQPDAKIPPNAKLTFEVELVDIDProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP3
Protein Size: 224
Purification: Affinity Purified