Geldanamycin, CAS 30562-34-6

Hsp90 inhibitor

Product Type: Inhibitor

CAS No.: 30562-34-6

MolecularFormula: C29H40N2O9

Molecular Weight: 560,6

Source: Produced by fermentation

Purity: >95%

Solubility: Slightly soluble in methanol, chloroform or DMSO (10 mg/ml); insoluble in water

Appearance: Yellow Solid

PubChem CID: 5288382

Scientific Background: Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.

References: 1. Whitesell L., et al. (1994) Proc. Natl. Acad. Sci. USA 91:8324.2. Neckers L. (2002) Trends Mol. Med. 8: S55.3. Mabjeesh N.J., et al. (2002) Cancer Res. 62: 2478.4. Chavany C., et al. 1996) Amer. Society Biochem Mol Bio. 9: 4974-4977.5. Villa R., et al. (2003) Carcinogenesis. 24(5): 851-9.6. Yamaki H., Iguchi-Ariga S.M., and Ariga H. (1989) J Antibiot (Tokyo). 42(4): 604-10.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-111A
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-111A
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)