GF109203X , CAS 133052-90-1

PKC kinase inhibitor

Product Type: Inhibitor

CAS No.: 133052-90-1

MolecularFormula: C25H24N4O2

Molecular Weight: 412,5

Source: Synthetic

Purity: ≥98% (TLC)

Solubility: Soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well)

Appearance: Red solid

PubChem CID: 2396

Scientific Background: GF109203X is a very potent inhibitor of protein kinase C; it is selective for the α and β1 isoforms; this could lead to an increase in autophagy. GF109203X is also an inhibitor of glycogen synthase kinase-3 (GSK-3) and has anti-inflammatory effects. It has also been seen to inhibit telomerase activity and necrosis.

References: 1. Toullec D., et al. (1991) J. Biol. Chem. 266(24): 15771–15781.2. Jacobson P.B., et al. (1995) J. Pharma. Exp. Ther. 275(2): 995–1002.3. Jiang Q., et al. (2011) Mol. Biol. Cell. 22(8): 1167–1180.4. Kuchera S., et al. (1993) Agents and Actions. 39 Spec No: C169–173.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-447-1MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-447-1MG
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK