GPX4 Inhibitor 17

Formulation: A solid

Purity: ≥98%

Formula Markup: C30H27ClFeN2O3

Formula Weight: 554,9

Shelf life (days): 1460

Notes: GPX4 inhibitor 17 is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4) and an inducer of ferroptosis.{67919} It inhibits GPX4 activity by 49.16% when used at a concentration of 1 µM. GPX4 inhibitor 17 (0.5 µM) increases the production of reactive oxygen species (ROS) and levels of malondialdehyde (MDA) in OS-RC-2 clear cell renal cell carcinoma cells. It induces ferroptosis in HT-1080 cells (IC50s = 0.007 and 1.486 µM, in the absence and presence of ferrostatin-1, respectively). GPX4 inhibitor 17 (20 mg/kg) reduces tumor volume and intratumoral GPX4 levels in an OS-RC-2 mouse xenograft model.

• Artikelnummer: CAY42006-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 42006-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK