GW2580, CAS 870483-87-7

cFMS kinase inhibitor

Product Type: Inhibitor

CAS No.: 870483-87-7

MolecularFormula: C20H22N4O3

Molecular Weight: 366,4

Source: Synthetic

Purity: ≥98% (HPLC)

Solubility: Soluble in DMSO: 10 mg/ml, clear (warmed)

Appearance: White to beige solid

PubChem CID: 11617559

Scientific Background: GW2580 is a potent and selective, ATP-competitive inhibitor of cFMS kinase. It also inhibits macrophage-colony stimulating factor receptor, M-CSF/ CSF-1. cFMS is a type III receptor tyrosine kinase that binds to M-CSF or CSF-1. Overexpression of CSF-1 and/or FMS has been implicated in a number of disease states.

References: 1. Conway J.G., et al. (2008) J. Pharm. Exp. Ther. 326(1): 41–50.2. Conway J.G., et al. (2005) Pro. Nat. Acad. Sci. USA. 102(44): 16078–16083.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-449-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-449-25MG
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK