Her2 / ErbB2 (phospho Tyr1248) antibody

Application Note: WB: 1:500-1:2000. ICC/IF: 1:100-1:500. IHC-P: 1:50-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 138

Form: Liquid

Buffer (with preservative): PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.

Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)

Background: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

Uniprot ID: P04626

Antigen Species: Human

Immunogen: A synthesized peptide derived from Human ERBB2(Accession P04626), corresponding to amino acid residues P1228-V1255.

Purification: Purified by sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns

Conjugation: Unconjugated

Full Name: erb-b2 receptor tyrosine kinase 2

• Artikelnummer: GTX03358-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX03358-100
• Green Labware: Nein
• Verpackungseinheit: 100 μl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Polyclonal
• Methode: Immunofluorescence, Immunohistochemistry (paraffin), Western Blotting, ELISA, Immunocytochemistry
• Isotyp: IgG
• Human Gene ID: 2064
• Wirt: Rabbit