Human PTPN12 protein, His tag and GST tag (active)

Species: Human

Application Note: Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate. The specific activity is > 15 μmoles/min/mg.

Form: Lyophilized powder

Buffer (with preservative): Batch dependent (please contact us for details)

Concentration:

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Uniprot ID: Q05209

Region Sequence: N-terminal polyhistidine and GST tag; Met1-Gln355 (AAA36529.1)

ExpressionSystem: Baculovirus-Insect Cells

Conjugation: Unconjugated

Full Name: protein tyrosine phosphatase non-receptor type 12

• Artikelnummer: GTX03561-PRO-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX03561-PRO-100
• Green Labware: Nein
• Verpackungseinheit: 100 μg
• Mengeneinheit: STK
• Methode: Functional Assay
• Human Gene ID: 5782