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Transthyretin Y78F Variant Filaments
Human Recombinant Transthyretin Y78F Variant Protein Filaments
Artikelnummer
STRSPR-465C
Verpackungseinheit
100 µg x2
Hersteller
Stressmarq Biosciences
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Target: Transthyretin.
Nature: Recombinant.
Swiss-Prot: P02766.
Expression System: E. coli.
Protein Length: Full length.
Purification: Ion-exchange Purified.
Purity: >95%.
Storage Buffer: PBS pH 7.4.
Protein Size: 15.887 kDa.
Conjugate: No Tag.
Cellular Localization: Cytoplasm, Extracellular exosome, Extracellular Region, Lysosome.
Scientific Background: Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer's Disease (6). The mutant variant Y78F indicates a destabilization of the contacts between the alpha-helix and AB loop and the body of the molecule, potentially leading to applications in immne therapy for FAP (7).
References: 1. Zeldenrust S.R., Benson M.D. (2010). Wiley. pp. 795–815. 2. Westermark P., Sletten K., Johansson B., Cornwell G.G. (1990). Proc. Natl. Acad. Sci. U.S.A. 87(7): 2843–5. 3. Andrade C. (1952). Brain. 75(3): 408–27. 4. Coelho T. (1996). Curr. Opin. Neurol. 9(5): 355–9. 5. Jacobson D.R, et. al. (1997). N. Engl. J. Med. 336(7): 466–73. 6. Li X. (2011). Mol Neurodegener. 6(1):79. 7. Terazaki H.,m et al. (2006) Lab Invest. 86(1): 23-31.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Nature: Recombinant.
Swiss-Prot: P02766.
Expression System: E. coli.
Protein Length: Full length.
Purification: Ion-exchange Purified.
Purity: >95%.
Storage Buffer: PBS pH 7.4.
Protein Size: 15.887 kDa.
Conjugate: No Tag.
Cellular Localization: Cytoplasm, Extracellular exosome, Extracellular Region, Lysosome.
Scientific Background: Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer's Disease (6). The mutant variant Y78F indicates a destabilization of the contacts between the alpha-helix and AB loop and the body of the molecule, potentially leading to applications in immne therapy for FAP (7).
References: 1. Zeldenrust S.R., Benson M.D. (2010). Wiley. pp. 795–815. 2. Westermark P., Sletten K., Johansson B., Cornwell G.G. (1990). Proc. Natl. Acad. Sci. U.S.A. 87(7): 2843–5. 3. Andrade C. (1952). Brain. 75(3): 408–27. 4. Coelho T. (1996). Curr. Opin. Neurol. 9(5): 355–9. 5. Jacobson D.R, et. al. (1997). N. Engl. J. Med. 336(7): 466–73. 6. Li X. (2011). Mol Neurodegener. 6(1):79. 7. Terazaki H.,m et al. (2006) Lab Invest. 86(1): 23-31.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
| Artikelnummer | STRSPR-465C |
|---|---|
| Hersteller | Stressmarq Biosciences |
| Hersteller Artikelnummer | SPR-465C |
| Green Labware | Nein |
| Verpackungseinheit | 100 µg x2 |
| Mengeneinheit | PAK |
| Reaktivität | Human |
| Methode | Western Blotting, In Vivo Assay, SDS-PAGE |
| Human Gene ID | 7276 |
| Produktinformation (PDF) |
|
| MSDS (PDF) | Download |
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Gernot Ensinger, M.Sc.
Laurent Haze
