ICG-001, CAS 847591-62-2

β-catenin inhibitor

Product Type: Inhibitor

CAS No.: 847591-62-2

MolecularFormula: C33H32N4O4

Molecular Weight: 548,63

Source: Synthetic

Purity: >98%

Solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol

Appearance: White solid

PubChem CID: 11238147

Scientific Background: Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.

References: 1. Emami K.H., et al. (2004) Proc. Natl. Acad. Sci. USA. 101(34): 12682-7. 2. De Sousa E.M., et al. (2011) Clin. Cancer Res. 17(4): 647-53. 3. Zhou B., et al. (2012) J. Biol. Chem. 287(10): 7026-38.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-387-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-387-5MG
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK