ICOS/NFAT Reporter-Jurkat Recombinant Cell Line

ICOS/NFAT Reporter-Jurkat Recombinant Cell Line
Artikelnummer
BPS79668
Verpackungseinheit
2 vials
Hersteller
BPS Bioscience

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Applications: Screen for agonists of ICOS signaling in a physiologically relevant cellular context
Characterize T cell-mediated immune responses of ICOS and its interaction with ICOSL

Background: ICOS is a costimulatory molecule of the CD28 cell surface receptor superfamily that is expressed on activated T-cells. ICOS is involved in T-cell responses upon binding with its ligand, ICOSL (also known as B7-H2, CD275), which is normally expressed on B-cells, dendritic cells and monocytes. ICOS expression confers an activated phenotype and a strong suppressive capacity to intra-tumoral regulatory T-cells. The ICOS/ICOSL pathway is a key target for cancer immunotherapy.

Description: Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of a chimeric receptor consisting human ICOS (also known as inducible T-cell costimulator or CD278, Genbank Accession #NM_012092) and the cytoplasmic domain of human CD3 zeta.

Format: Each vial contains 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.

Host Cell Line: Jurkat

Mycoplasma Testing: This cell line has been screened using the MycoAlert™ Mycoplasma Detection Kit (Lonza, #LT07-118) to confirm the absence of Mycoplasma contamination.

Storage Stability: Store in liquid nitrogen immediately upon receipt.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: BSL-1
Mehr Informationen
Artikelnummer BPS79668
Hersteller BPS Bioscience
Hersteller Artikelnummer 79668
Verpackungseinheit 2 vials
Mengeneinheit PAK
Wirt Human
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