Product Type: Inhibitor
CAS No.: 5852-78-8
MolecularFormula: C10H7NO3
Molecular Weight: 189,2
Source: Synthetic
Purity: ≥98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (20 mg/ml)
Appearance: Yellow powder
PubChem CID: 459617
Scientific Background: IOX1 is a cell permeable inhibitor of the JMJD family of 2-oxoglutarate-dependent histone demethylases (IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 M for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1). It is a broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling (1).
References: 1. King O.N., et al. (2010) PLoS One. 5: e15535.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.