KCNQ1 Antibody, Clone N37A/10: APC

Mouse Anti-Human KCNQ1 Monoclonal IgG1

Target: KCNQ1

Conjugate: APC

Product Type: Monoclonal

Clone Number: N37A/10 (Formerly sold as S37A-10)

Immunogen: Fusion protein amino acids 2-101 of human KCNQ1

Swiss-Prot: P51787

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~75kDa.

Cellular Localization: Cell Membrane,Cytoplasmic Vesicle Membrane

Scientific Background: Kv7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons (1) among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction (2, 3).

References: 1. Lang F., Vallon V., Knipper M., Wagenmann P. (2007) Am J Physiol. 293(4): C1187-1208.2. Kurokawa J., et al. (2009) Channels (Austin). 3(1): 16-24.3. Silva J., and Rudy Y. (2005) Circulation. 112(10): 1384-1391.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-307D-APC
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-307D-APC
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus), Hamster
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunoprecipitation, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 3784
• Wirt: Mouse