KCNQ4 Antibody, Clone N43/6

Mouse Anti-Human KCNQ4 Monoclonal IgG1

Target: KCNQ4

Conjugate: Unconjugated

Product Type: Monoclonal

Clone Number: N43/6 (Formerly sold as S43-6)

Immunogen: Fusion protein amino acids 2-77 of human KCNQ4

Swiss-Prot: P56696

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~77kDa.

Cellular Localization: Plasma Membrane,Basal Cell Membrane

Scientific Background: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability (1), particularly in sensory cells of the cochlea (2). The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug (3).

References: 1. Hernandez C.C., Zaiko O., Tolstykh G.P., Shapiro M.S. (2008) J Physiol. 586(7): 1811-1821.2. Kharkovets T., et al. (2006) EMBO J. 25(3): 642-652.3. Tatulian L., Delmas P., Abogadie F.C., Brown D.A. (2001) J Neuroscience. 21(15): 5535-5545.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-309D
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-309D
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunoprecipitation, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 9132
• Wirt: Mouse