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Encompassing Amino Acids: 2-186
Description: Human KRAS also known as C-K-RAS, CFC2, and K-RAS2A, GenBank Accession No. NM_033360, a.a. 2-186, with Gly12 to Cys mutation and N-terminal His-tag, expressed in an E. coli expression system. MW=23 kDa. The KRAS (G12C) mutant is constitutively active.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 122 mM NaCl, 2.2 mM KCl and 20% glycerol.
Genbank: NM_033360
Storage Stability: At least 6 months at -70°C.
Supplied As: Aqueous buffer solution.
Tags: N-terminal His-Tag
Uniprot: P01116
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Lito, P., et al., Science. 2016 Feb;351(6273):604-608.
2. Dogan, S., et al., Clinical Cancer Research. 2012 Nov;18(22):6169-6177.