Product Type: Inhibitor
CAS No.: 108068-98-0
MolecularFormula: C32H31N3O5
Molecular Weight: 537,6
Source: Synthetic
Purity: ≥98% (TLC)
Solubility: Soluble in methanol: clear colorless solution at 5 mg/ml
Appearance: White powder
PubChem CID: 3844
Scientific Background: KT5720 is a potent and selective inhibitor of protein kinase A (PKA). This compound blocks PKA signaling through competitive inhibition. It causes no significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (mlCK). KT5720 has been shown to reversibly arrests human skin fibroblasts in the G1 phase. It is cell permeable.
References: 1. Kase H., et al. (1987) Biochem. Biophys. Res. Comm. 142(2): 436–440.2. Gadbois D.M., Crissman H.A., Tobey R.A., & Bradbury E.M. (1992) Pro. Na. Aca. Sci. USA. 89(18): 8626–8630.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.