Lapatinib, CAS 231277-92-2

EGFR, HER2 inhibitor

Product Type: Inhibitor

CAS No.: 231277-92-2

MolecularFormula: C29H26ClFN4O4S

Molecular Weight: 581,1

Source: Synthetic

Purity: ≥99%

Solubility: Solubility in water is 0.007 mg/ml and in 0.1N HCl is 0.001 mg/ml at 25° C

Appearance: Yellow crystalline solid

PubChem CID: 208908

Scientific Background: Lapatinib is a tyrosine kinase inhibitor. Specifically, it interrupts the ErbB/neu and epidermal growth factor receptor (EGFR) pathways. It is an antineoplastic agent used in breast cancer research. In solid tumor cells, Lapatinib binds to the ATP-binding pocket of the protein kinase domains on EGFR/ErbB, preventing self-phosphorylation.

References: 1. Chien A.J., et al. (2014) J. Clin. Oncol: J. Am. Clin. Oncol. 32(14): 1472–1479. 2. Dahal B.K., et al. (2010) Am. J. Resp. Critical Care Med. 181(2): 158–167.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-459-10MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-459-10MG
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK