LATS1 Polyclonal Antibody, Rabbit

Abbreviation: LATS1

Target Synonym: LATS1;WARTS;wts

Conjugation: Unconjugated

UNIProt ID: O95835

Background: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Concentration: 1mg/mL

Immunogen: A synthetic peptide of human LATS1

Dilution: WB 1:500-1:2000,IHC 1:50-1:200

• Artikelnummer: ELSE-AB-93222-120
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-E-AB-93222-120
• Green Labware: Nein
• Verpackungseinheit: 120 µl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Polyclonal
• Methode: Western Blotting, Immunohistochemistry
• Isotyp: IgG
• Wirt: Rabbit