Product Type: Inhibitor
CAS No.: 668467-91-2
MolecularFormula: C17H11Cl3N2O3
Molecular Weight: 397,6
Source: Synthetic
Purity: >98%
Solubility: Soluble in 20 mg/ml DMSO
Appearance: Yellow Powder
PubChem CID: 16760696
Scientific Background: Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable.
References: 1. Liu Y., et al. (2003) Chem. Biol. 10: 837.2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109.3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.