Linopirdine dihydrochloride, CAS 113168-57-3

KCNQ Channel Blocker

Product Type: Blocker

CAS No.: 113168-57-3

MolecularFormula: C26H23Cl2N3O

Molecular Weight: 464,4

Source: Synthetic

Purity: >98% (HPLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (25 mg/ml): or water (25 mg/ml)

Appearance: Off-white powder

PubChem CID: 14209557

Scientific Background: Linopirdine increases acetylcholine release and improves performance in animal models of learning and memory via blockade of Kv7 (KCNQ) voltage-gated potassium channels (1-3). Linopirdine is a state-dependent blocker favoring activated single subunits of the channel (4).

References: 1. D Kristufeck et al. J. Neurochem. 1999 72:20832. HS Wang et al. Science 1998 282:18903. DJ Fontana et al. Pharmacol. Biochem. Behav. 1994 49:10754. DL Greene et al. J. Pharmacol. Exp. Ther. 2017 362:177

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-629-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-629-5MG
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK