Macimorelin (acetate), CAS 945212-59-9

Formulation: A solid

Formal Name: 2-methylalanyl-N-[(1R)-1-(formylamino)-2-(1H-indol-3-yl)ethyl]-D-typtophanamide, acetate

Purity: ≥98%

Formula Markup: C26H30N6O3 • C2H4O2

Formula Weight: 534,6

Shelf life (days): 1460

CAS Number: 945212-59-9

Notes: Macimorelin is a growth hormone secretagogue and agonist of growth hormone secretagogue receptor 1a (GHS-R1a).{61221} It binds to GHS-R1a (IC50 = 123 nM for the human receptor). Oral administration of macimorelin (1 mg/kg) increases plasma growth hormone levels in dogs. It decreases gastric acid secretion in pylorus-ligated rats when administered intracerebroventricularly at doses of 0.01 or 1 nmol/animal.{69975} Macimorelin (10 mg/kg) increases acute food intake and body weight in mice.{69976} It decreases the number and total duration of seizures in mice induced with dopamine D1 receptor kindling using SKF 81297.{69977} Formulations containing macimorelin have been used in the diagnosis of adult growth hormone deficiency.

• Artikelnummer: CAY41886-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41886-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK