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MAPK8IP1 Polyclonal Antibody, Rabbit
MAPK8IP1 Polyclonal Antibody, Rabbit
Artikelnummer
ELSE-AB-92930-120
Verpackungseinheit
120 µl
Hersteller
Elabscience Biotechnology
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Abbreviation: MAPK8IP1
Target Synonym: MAPK8IP1;IB1;JIP-1;JIP1;PRKM8IP
Conjugation: Unconjugated
UNIProt ID: Q9UQF2
Background: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human MAPK8IP1
Dilution: WB 1:200-1:2000
Target Synonym: MAPK8IP1;IB1;JIP-1;JIP1;PRKM8IP
Conjugation: Unconjugated
UNIProt ID: Q9UQF2
Background: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human MAPK8IP1
Dilution: WB 1:200-1:2000
| Artikelnummer | ELSE-AB-92930-120 |
|---|---|
| Hersteller | Elabscience Biotechnology |
| Hersteller Artikelnummer | ELA-E-AB-92930-120 |
| Green Labware | Nein |
| Verpackungseinheit | 120 µl |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine) |
| Klonalität | Polyclonal |
| Methode | Western Blotting |
| Isotyp | IgG |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
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