MDC1 Antibody, Clone P2B11: Biotin

Mouse Anti-Mouse MDC1 Monoclonal IgG1

Target: MDC1

Conjugate: Biotin

Product Type: Monoclonal

Clone Number: P2B11

Immunogen: GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus

Swiss-Prot: Q5PSV9

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~184kDa. This antibody recognizes MDC1 at and around the N-terminus.

Cellular Localization: Nucleus

Scientific Background: MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139.

References: 1. Lou Z., et al. (2004) J Biol Chem. 279(45): 46359-46362.2. Luo K., Yuan J, Lou Z. (2011) J Biol Chem. 286(32): 28192-28199.3. Strauss C., Halevy T., Macarov M., Argaman L., and Goldbery M. (2011) DNA Repair (Amst.). 10(8): 806-814.4. Wilson K.A., et al. (2011) Mol Cancer Res. 9(6): 766-781.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-197D-BI
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-197D-BI
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Primate, Cow (Bovine)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 240087
• Wirt: Mouse