English
MLKL antibody (HL1849)
MLKL antibody (HL1849)
Artikelnummer
GTX637574-100
Verpackungseinheit
100 μl
Hersteller
GeneTex
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Clone Name: HL1849
Light Chain: Kappa
Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 54
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Uniprot ID: Q8NB16
Antigen Species: Human
Immunogen: Recombinant fragment of human MLKL
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: mixed lineage kinase domain like pseudokinase
Light Chain: Kappa
Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 54
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Uniprot ID: Q8NB16
Antigen Species: Human
Immunogen: Recombinant fragment of human MLKL
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: mixed lineage kinase domain like pseudokinase
| Artikelnummer | GTX637574-100 |
|---|---|
| Hersteller | GeneTex |
| Hersteller Artikelnummer | GTX637574-100 |
| Green Labware | Nein |
| Verpackungseinheit | 100 μl |
| Mengeneinheit | STK |
| Reaktivität | Human |
| Klonalität | Monoclonal |
| Methode | Immunofluorescence, Immunohistochemistry (paraffin), Western Blotting, Immunocytochemistry |
| Isotyp | IgG |
| Human Gene ID | 197259 |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
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