Mouse anti-beta-Catenin, clone 9F2 (Monoclonal)

Clone Number: 9F2

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: 100 ug/ ml

Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide

Additional info: Beta-catenin belongs together with alpha- and gamma-catenin to the catenin family. Catenins mediates cell-cell adhesion by interaction with cadherins. Beta-catenin is highly homologous to gamma-catenin (plakoglobin) although its function differs from that of plakoglobin. Whereas plakoglobin has been found to suppress tumorigenicity, beta-catenin potentiates hyperproliferation and tumor formation. In the nucleus beta-catenin it complexes with transcription factors and thus regulates the expression of specific genes. By its dual role, i.e. a structural role in cell-cell junctions and a regulatory role in the nucleus, beta-catenin can transduce changes in cell adhesion and junction formation to control transmembrane signalling and gene expression.

References: Johnson; K et al. Exp Cell Res 1993; 207: 252 /Sacco, P et al J Biol Chem 1995, 270: 20201 /Hakuno; M et al. Br J Dermatol 2000; 142: 702

• Artikelnummer: SANMON3055
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON3055
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunoprecipitation, Western Blotting, Flow Cytometry
• Isotyp: IgG1
• Wirt: Mouse